Abstracts

Presenters at this year's FIP

B.R.A.I.N.

B2. Measurement and modulation of the excitability of a brainstem motoneuron pool in-vivo

Jasmin A. Aggarwal, Hattie Liu, Gaspard Montandon, Richard L. Horner

Poster_session_2 Neuro

B17. Multiplexed Coding Using Differentially Synchronized Spikes

Dhekra Al-Basha, Milad Lankarany, Stephanie Ratté, Steven A. Prescott

Poster_session_1 Neuro

B3. Neural activity of the subthalamic nucleus in a preference-based decision-making task.

Tameem M. Alozzi, Luis F. Botero Posada, Adriana L. Lopez Rios, William D. Hutchison

Poster_session_1 Neuro

B5. It’s about time: PKA-dependent LTP integrates the timing of stimuli via LIMK1

Sammy Cai, Graham L. Collingridge, Zhengping Jia

Poster_session_1 Neuro

2.5. THE role of Neuroligin 2 and inhibitory transmission in the function of thalamic circuitry epilepsy

Feng Cao, Jia Liu, Zhengping Jia

Oral_2 Neuro

B19. Deciphering the contributions of Oriens-Lacunosum/Moleulaire (OLM) cells during Local Field Potential (LFP) theta rhythms in CA1 hippocampus

Alexandra Chatzikalymniou, Frances Skinner

Poster_session_1 Neuro

B8. Synaptic plasticity in Alzheimer's disease

Dalya Cohen, Zheng-Ping Jia, Graham Collingridge

Poster_session_2 Neuro

B1. The role of endogenous cellular prion protein in brain synaptic function

Aeen Ebrahim Amini, John Georgiou, Changiz Taghibiglou, Graham L. Collingridge

Poster_session_1 Neuro

B14. Novel Approach to developing Undergraduate Research Skills in First-year

Riya George, Michelle French

Poster_session_2 Neuro

B22. Simulating In Vivo-Like States for Hippocampal CA1 Interneuron Specific 3 Cells

Alexandre Guet-McCreight, Lisa Topolnik, Frances K. Skinner

Poster_session_2 Neuro

B18. Involvement of synaptic vesicle and receptor trafficking system in multiple sclerosis

Anlong Jiang, Fang Liu

Poster_session_2 Neuro

B15. Pre-existing inflammation exacerbates cognitive dysfunction after anesthesia in mice

Shahin Khodaei, Yu-Feng Xie, Dian-Shi Wang, Beverley Orser

Poster_session_1 Neuro

3.4. How an asymmetric L1 motor circuit generates symmetrical motor output

Yangning Lu, Asuka Guan, Daniel Witvliet, Ben Mulcahy, Jin Meng, Jun Meng, Quan Wen, Aravinthan Samuel, Mei Zhen

Oral_3 Neuro

B11. The adult mammalian digit tip blastema consists of pre-existing mesenchymal cells that are recruited for regeneration

Neemat Mahmud, Mekayla A. Storer, Scott A. Yuzwa, Michael J. Borrett, Dina Karamboulas, David R. Kaplan, Freda D. Miller

Poster_session_1 Neuro

B12. Neuropathic pain caused by Cl- dysregulation in both sexes; overcoming degenerate regulation by targeting KCC2

Josiane C.S. Mapplebeck, Louis-Etienne Lorenzo, Kwan Lee, Yves De Koninck, Steve A. Prescott, Michael W. Salter

Poster_session_2 Neuro

B24. The time course of behavioural impairment in mice following mild traumatic brain injury

Miranda Mellerup, Lisa Gazdzinski, John Sled, Anne Wheeler

Poster_session_2 Neuro

B4. The central role of the descending interneuron AVA in the C. elegans motor circuit

Jun Meng, Wesley Hung, Sonia El Mouridi, Marine Mercier, Thomas Boulin, Shangbang Gao, Mei Zhen

Poster_session_2 Neuro

B9. The Effects of Viral Mimics on Pro-Inflammatory Response Genes Expression in Astrocytes

Andrada Naghi, Güínever Eustáquio Do Império, Stephen G Matthews

Poster_session_1 Neuro

B23. Zebrafish Reverse Translation Models for Major Depressive Disorders (MDD)

Vijay Narasimhan, Jane Foster, Sidney Kennedy, Xiao-Yan Wen

Poster_session_1 Neuro

B20. Anesthetic activation of GABAA receptors in astrocytes causes persistent GABAA receptor hyperactivity in neurons in mice

Arsène Pinguelo, Sean C. Haffey, Irene Lecker, Yu-Feng Xie, Dian-Shi Wang, Beverley A. Orser

Poster_session_2 Neuro

B6. Genome-wide association study for variants associated with reading abilities

Kaitlyn Price, Karen G Wigg, Virginia Misener, Kirsten Blokland, Elizabeth Kerr, Sharon Guger, Maureen W Lovett, Cathy L Barr

Poster_session_2 Neuro

B10. Investigating the function of the complement cascade in hippocampal synaptic plasticity

Eric W Salter, Sun-Lim Choi, John Georgiou, Graham L Collingridge

Poster_session_2 Neuro

1.2. SIRT3 – Sex Specific Role in Behaviour?

Elena Sidorova, Richard Logan, James Eubanks

Oral_1 Neuro

B7. The role of the nicotinic α5 subunit in key midbrain structures implicated in nicotine response

Sanghavy Sivakumaran, Daniel W. Sparks, Evelyn K. Lambe

Poster_session_1 Neuro

B25. The Effect of Traumatic Brain Injury on Superficial White Matter in Youth: Towards a Personalized Injury Profile.

Sonja Stojanovski, Arash Nazeri, Christian Lepage, Aristotle Voineskos, Anne L Wheeler

Poster_session_1 Neuro

2.1. Modelling the impact of new learning and neurogenesis on memory stability in the hippocampus.

Lina M. Tran, Sheena A. Josselyn, Blake A. Richards, Paul W. Frankland

Oral_2 Neuro

B16. Prefrontal responses to optogenetic release of endogenous acetylcholine depend on expression of alpha5 nicotinic receptors

Sridevi Venkatesan, Daniel W. Sparks, Evelyn K. Lambe

Poster_session_2 Neuro

B21. Immunogenic analysis of a CaV2.1 calcium channel C-terminal synaptic vesicle binding site

H. K.-H. MAH, C. SNIDAL, R. H.-C. CHEN, Q. LI, E. F. STANLEY

Poster_session_1 Neuro

Cardiovascular & Respiratory

C5. The requirement of B-cells for blood pressure homeostasis

Luke S Dingwell, Eric A Shikatani, Rickvinder Besla, Andrew S Levy, Danny Dinh, Abdul Momen, Hangjun Zhang, Talat Afroze, Michelle B Chen, Nicholas Maksimowski, Craig A Simmons, Filio Billia, Jennifer L Gommerman, Rohan John, Scott Heximer, James Scholey, Steffen-Sebastian Bolz, Clinton Robbins, Mansoor Husain

Poster_session_1 Cardio

1.1. Nanoscale imaging of essential sarcoplasmic reticulum proteins in pressure overload cardiomyocytes

Sina Hadipour-Lakmehsari, Amine Driouchi, Shin-Haw Lee, Uros Kuzmanov, Neal I. Callaghan, Craig A. Simmons, Chris M. Yip, Anthony O. Gramolini

Oral_1 Cardio

C1. Global proteomic and post-translational modification analysis of human ischemic cardiomyopathy

Da Hye Kim, Uros Kuzmanov, Hadipour-Lakmehsari, Gavin Y. Oudit, Anthony O. Gramolini

Poster_session_1 Cardio

C6. Determining the Role of Gαi3 in Ischemia-Reperfusion Injury

Dylan Langburt, Scott Heximer

Poster_session_2 Cardio

3.1. REEP5 depletion causes sarcoplasmic reticulum vacuolization and cardiac functional defects

Shin-Haw Lee, Sina Hadipour-Lakmehsari, Natalie Gibb, Allen C.T. Teng, Tetsuaki Miyake, Jake Cosme, Jessica C. Yu, Peter Liu, Filio Billia, Rodrigo Fernandez-Gonzalez, Igor Stagljar, Parveen Sharma, Thomas Kislinger, Ian C. Scott, Anthony O. Gramolini

Oral_3 Cardio

C4. Degradation of Phospholamban mutants in cardiac muscle cells

Xavier Lee, Allen C.T. Teng, Anthony Gramolini

Poster_session_2 Cardio

C2. Alpha 11 integrin a mediator of myofibrolastic transformation and fibrosis formation in the failing heart.

Patrick Meagher BSc (Honours), Robert Civitarese MSc, Jean-Francios Desjardin MSc, Golam Kabir Msc MD, Kim Connelly MBBS PhD

Poster_session_2 Cardio

2.2. The cystic fibrosis transmembrane conductance regulator (CFTR) as a potential link between the molecular clock and myogenic responsiveness in cerebral arteries

Chloe Ng, Jeffrey T. Kroetsch, Darcy Lidington, Steffen-Sebastian Bolz

Oral_2 Cardio

C10. Preclinical development of a small molecule identified from a zebrafish screen as a novel candidate drug for sepsis targeting vascular leakage

Anju M Philip, Patricia Gali, Yuexin Shan, Claudia dosSantos, Xiao-Yan Wen

Poster_session_1 Cardio

C3. The role of fibroblasts in cardiac fibrosis

Haisam Shah, Shafkat Choudhury, Hangjun Zhang, Meghan McFadden, Yuqing Zhou, Anthony Gramolini, Scott Heximer

Poster_session_1 Cardio

C7. Role of somitic mesoderm-derived aortic Sca-1+ progenitor cells in vascular disease

Sarah K. Steinbach, Tao Wang, Martha H. Carruthers, Angela Li, Rickvinder Besla, Adam P. Johnston, Clinton S. Robbins, Mansoor Husain

Poster_session_1 Cardio

C9. Preliminary investigation of the utility of MRI for measuring the hematocrit in fetal anemia

Jiawei Xu, An Qi Duan, Johannes Keunen, Sharon Portnoy, John Sled, John Kingdom, Christopher K. Macgowan, Mike Seed

Poster_session_2 Cardio

C8. Cardioprotective benefits of combined treatment with glucagon-like peptide-1 receptor agonist and sodium glucose transporter 2 inhibitor in mice

Dorrin Zarrin Khat, Abdul Momen, Muhammad A. Siraj, Sina Hadipour-Lakmehsari, Mark J. Chandy, Mansoor Husain

Poster_session_2 Cardio

Endocrinology & Diabetes

2.3. Acute Exposure to Fish Oil Supplements Protect High Fat Diet Impaired Pancreatic Beta Cell Function

Dana Al Rijjal, Ying Liu, Michael Wheeler

Oral_2 Endo

E15. Lactobacillus gasseri in the upper small intestine impacts an ACSL3-dependent fatty acid sensing pathway that regulates whole-body glucose homeostasis

Paige V. Bauer, Frank A. Duca, T. M. Zaved Waise, Helen J. Dranse, Brittany A. Rasmussen, Akshita Puri, Mozhgan Rasti, Catherine A. O’Brien, Tony K. T. Lam

Poster_session_2 Endo

E5. The Role of Secretagogin in Circadian GLP-1 Secretion

Andrew Biancolin, Emilia Mitova, Patricia Brubaker

Poster_session_1 Endo

E8. Assessing the regulatory role of Munc18-1 in glucagon-like peptide-1 secretion from the intestinal L cell

Jhenielle Campbell, Patricia Brubaker

Poster_session_2 Endo

E6. Hypothalamic BMAL1-knockout cell lines for the study of circadian feeding regulation

Matthew N. Clemenzi, Erika K. Tse, Jennifer A. Chalmers, Neruja Loganathan, Ashkan Salehi, Alexandre Martchenko, Patricia L. Brubaker, Denise D. Belsham

Poster_session_2 Endo

3.2. Treatment of Glucagon-like Peptide-2 and Epidermal Growth Factor Simultaneously Increases Small Intestine Growth Synergistically in Mice

Zivit Fesler, Patricia L Brubaker

Oral_3 Endo

E11. Autophagy Related Protein 16L1 (Atg16L1) Depletion Induces Insulin Resistance Through Decreased IRS Expression

Scott Frendo-Cumbo, Javier Jaldin-Fincati, John H Brumell, Amira Klip

Poster_session_1 Endo

E14. GABA: Potential Agent of β-Cell Proliferation

Hima Gohil, Ashley Untereiner, Alpana Bhattacharjee, Feihan Dai, Ying Liu, and Michael Wheeler

Poster_session_2 Endo

E3. Bisphenol A increases AgRP mRNA levels in hypothalamic neurons through MAP kinases, JNK and ERK

Neruja Loganathan, Emma McIlwraith, Denise Belsham

Poster_session_1 Endo

E7. Lipid absorption and its connection to the intestinal epithelial insulin-like growth factor-1 receptor

Melanie A Markovic, Patricia L Brubaker

Poster_session_1 Endo

E10. Circadian secretion of glucagon-like peptide-1 is essential to maintaining diurnal metabolic homeostasis

Alexandre Martchenko, Matthew Clemenzi, Patrick, Patricia L. Brubaker

Poster_session_2 Endo

1.3. Modeling pancreatic development using hESC and patient specific iPSC

Emily McGaugh, Simon Kelley, April Craft, Maria Cristina Nostro

Oral_1 Endo

E13. Elucidating pancreatic lineage commitment using hESC directed differentiation

Frankie Poon, Roman Korytnikov, Cristina Nostro

Poster_session_1 Endo

E12. NOD1 mediates insulin resistance in response to circulating free fatty acids

Sydney Rivers, Lucy Shu Nga Yeung, Yusaku Mori, Kenny Chan, Dana Philpott, Amira Klip, and Adria Giacca

Poster_session_2 Endo

E1. Rescuing the bisphenol A mediated dysregulation of the pro-opiomelanocortin gene with anti-inflammatory compounds in hypothalamic neurons

Ashkan Salehi, Denise D. Belsham

Poster_session_1 Endo

E2. Vulnerability of insulin signal transduction during insulin resistance and its consequences on GLUT4 translocation

Victoria Tokarz, Javier Jaldin-Fincati, Zhi Liu, Amira Klip

Poster_session_2 Endo

E4. BPA, palmitate and nitric oxide induce spexin, GalR2 and GalR3 mRNA expression in hypothalamic neurons

Andy Tran, Neruja Loganathan, Emma Mcilwraith, Denise D. Belsham

Poster_session_2 Endo

E9. The effect of resveratrol on reducing neointimal growth after femoral artery injury is abolished in AMPKα2 knock-out mice

Liwei Zhou, June Guo, Hangjun Zhang, Scott Heximer, Adria Giacca

Poster_session_1 Endo

Reproduction & Development

1.4. Developing a Novel Screening Tool for Preterm Birth: Detecting Changes of the Extracellular Matrix in the Murine Cervix by Biochemical Analyses & Magnetic Resonance Imaging (MRI) During Term and Preterm Labor

Antara Chatterjee, Kartik Jhaveri, John Sled, Wendy Whittle, Stephen Lye, Oksana Shynlova

Oral_1 Repro

3.3. Using pluripotent stem cell-derived kidney organoids to model kidney injury

Theresa Chow, Jennifer Whiteley, Ian Rogers

Oral_3 Repro

R10. Antenatal synthetic glucocorticoid exposure modifies gene expression at the post-natal blood-testes barrier

Margaret E. Eng, Alice Kostaki, Stephen G. Matthews

Poster_session_2 Repro

R11. Optimizing pancreatic decellularization for examining the role of the extracellular matrix in islet maintenance and maturation in vitro

Amanda Fantin, Jennifer Whiteley, Ian Rogers

Poster_session_1 Repro

R9. Differential effects of decidual cytokines responsible for the infiltration of maternal peripheral leukocytes during human labour

Tali Farine, Oksana Shynlova, Stephen Lye

Poster_session_1 Repro

R13. Differential DNA Methylation Signatures Following Prenatal Exposure to Single-course Antenatal Glucocorticoids in Humans and Guinea Pigs

Bona Kim, Alisa Kostaki, Stephen Matthews

Repro

R3. Exploring the impact of coQ and Pdss2 deficiency on preimplantation embryo development and maternal-zygotic transition

Kyunga Kim, Andrea Jurisicova

Poster_session_1 Repro

R1. Placental subtypes of small-for-gestational-age pregnancies

Katherine Leavey, Isaac Gibbs, Samantha Benton, David Grynspan, Shannon Bainbridge, Brian Cox

Poster_session_1 Repro

R2. Gene regulation of phoenixin by bisphenol A, palmitate and oleate in hypothalamic neurons

Emma McIlwraith, Neruja Loganathan, Denise D. Belsham

Poster_session_2 Repro

R6. The role of BRCA1 on infertility and mitochondrial function

Rosanne McQuaid, Kyunga Kim, Elina Kadriu, Nicole Zhang, Taline Naranian, Razqallah Hakem, Andrea Jurisicova

Poster_session_2 Repro

R12. Generating and characterizing induced pluripotent stem cells (iPSCs) from umbilical cord mesenchymal stromal cells (UCT-MSCs)

Aisha Mohamed, Theresa Chow, Tonya Bongolan, Amanda Fantin, Jennifer Whiteley, Ian Rogers

Poster_session_2 Repro

R7. Characterizing Endometrial Receptivity of Primary Human Endometrial Cells In Vitro from Women with Implantation Failure

Tina Tu-Thu Ngoc Nguyen, Stewart J. Russell, Clifford Librach

Poster_session_1 Repro

2.4. Single-Cell Transcriptomic Assessment of Stem Cells Re-isolated from Murine Embryos to Determine the Influence of Microenvironments on Stem Cell Developmental Trajectories

Ursula Nosi, Fredrik Lanner, Brian Cox

Oral_2 Repro

R8. Progesterone Receptor Isoforms PRA and PRB Differentially Regulate Connexin 43 Expression and Intracellular Distribution in Breast Cancer Cells

Justin Rondeau, Lubna Nadeem, Stephen Lye

Poster_session_2 Repro

R5. Acid sphingomyelinase deficiency results in abnormal placental development and a growth restricted fetus that cannot be rescued in a WT uterine environment

Isidora Rovic, Han Li, Katherine Szelag, Andrea Jurisicova

Poster_session_1 Repro

R4. Meta analysis of microarray data of BMP4 treated human embryonic stem cells shows poor evidence for trophoblast cell types.

Frances Wong, Brian Cox

Poster_session_2 Repro